Diazepam is N-demethylated by CYP3A4 and 2C19 on the Lively metabolite N-desmethyldiazepam, and is particularly hydroxylated by CYP3A4 towards the active metabolite temazepam. N-desmethyldiazepam and temazepam are both equally more metabolized to oxazepam. Temazepam and oxazepam are mostly removed by glucuronidation.Advise the two clients and careg

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